Article
Sequence diversity and linkage disequilibrium within the merozoite surface protein-1 (Msp-1) locus of Plasmodium falciparum: a longitudinal study in Brazil.
The Journal of eukaryotic microbiology - 1 Jan 2000
Da Silveira L A, Ribeiro W L, Kirchgatter K, Wunderlich G, Matsuoka H, Tanabe K, Ferreira M U
Abstract excerpt
The merozoite surface protein-1 (MSP-1) is a major vaccine candidate for the asexual blood stage of malaria. We examined both the extent of sequence diversity in block 17, the 3' end of Msp-1 gene coding for a 19-kDa polypeptide (MSP-1(19)) putatively involved in red blood cell binding, and the patterns of linkage disequilibrium between polymorphic sites throughout the Msp-1 locus. The parasite population sample...
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