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Article

Loss of a single allele for Ku80 leads to progenitor dysfunction and accelerated aging in skeletal muscle.

EMBO molecular medicine - 1 Sept 2012

Didier Nathalie, Hourdé Christophe, Amthor Helge, Marazzi Giovanna, Sassoon David

Abstract excerpt

Muscle wasting is a major cause of morbidity in the elderly. Ku80 is required for DNA double strand repair and is implicated in telomere maintenance. Complete loss-of-function leads to reduced post-natal growth and severe progeria in mice. We examined the role of Ku80 in age-related skeletal muscle atrophy. While complete loss of Ku80 leads to pronounced aging in muscle as expected, accompanied by accumulation of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22915554
DOI: 10.1002/emmm.201101075
PMCID: PMC3491824

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Loss of a single allele for Ku80 leads to progenitor dysfunction and accelerated aging in skeletal muscle.PMID 22915554Read ↗

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