Article
Isolated KRAS and NRAS mutations in adults with monocytosis and/or cytopenia(s).
Haematologica - 1 Jun 2026
Wang Sa A, Ok Chi Young, Tsai Harrison K, Loayza Naima, Daneshpajouhnejad Parnaz, Seth Neha, Cantu Miguel D, Bagg Adam, Tam Wayne, Weinberg Olga, Barone Paul D, Geyer Julia T, Lindsley Coleman R, Montalban-Bravo Guillermo, Simon Cody R, Arber Daniel A, Bueso-Ramos Carlos E, Hsi Eric D, Foucar Kathryn, Orazi Attilio, Patnaik Mrinal M, Hasserjian Robert P, Reichard Kaaren K
Abstract excerpt
NRAS and KRAS mutations, commonly identified alongside ancestral co-mutations, are generally regarded as pathogenic in adults presenting with monocytosis and/or cytopenia(s). However, their significance in isolation is not well defined. We studied a multi-institutional cohort of 52 patients with isolated RAS mutations and found that 26 (50%) did not meet diagnostic criteria for a myeloid neoplasm. Compared to...
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