Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Oncogenic NRAS, KRAS, and HRAS exhibit different leukemogenic potentials in mice.

Cancer research - 1 Aug 2007

Parikh Chaitali, Subrahmanyam Ramesh, Ren Ruibao

Abstract excerpt

RAS proteins are small GTPases that play a central role in transducing signals that regulate cell proliferation, survival, and differentiation. The RAS proteins interact with a common set of activators and effectors; however, they associate with different microdomains of the plasma membrane as well as other endomembranes and are capable of generating distinct signal outputs. Mutations that result in constitutive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Southern
Share to Bone Marrow
Share to Bone Marrow Transplantation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, ras

Share to Leukemia, Myeloid

Share to Mice, Inbred BALB C

Share to Neoplasm Invasiveness

Share to Retroviridae

Source

Open in PubMed Open full text

Identifiers

PMID: 17671181
DOI: 10.1158/0008-5472.CAN-07-0778
PMCID: PMC2662707

Genes

HRAS
KRAS
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oncogenic NRAS, KRAS, and HRAS exhibit different leukemogenic potentials in mice.PMID 17671181Read ↗

Oncogenic NRAS rapidly and efficiently induces CMML- and AML-like diseases in mice.Semantic proximity Read ↗

Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus.Semantic proximity Read ↗

Mechanistic and Preclinical Insights from Mouse Models of Hematologic Cancer Characterized by Hyperactive Ras.Semantic proximity Read ↗

Targeting oncogenic Ras signaling in hematologic malignancies.Semantic proximity Read ↗

Endogenous oncogenic Nras mutation promotes aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemia.Semantic proximity Read ↗

The mystery of oncogenic KRAS: Lessons from studying its wild-type counter part.Semantic proximity Read ↗

KRAS (G12D) cooperates with AML1/ETO to initiate a mouse model mimicking human acute myeloid leukemia.Semantic proximity Read ↗

Nras(G12D/+) promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions.Semantic proximity Read ↗

Endogenous oncogenic Nras mutation initiates hematopoietic malignancies in a dose- and cell type-dependent manner.Semantic proximity Read ↗

Targeting Ras in myeloid leukemias.Semantic proximity Read ↗

Distinct requirements of hematopoietic stem cell activity and Nras G12D signaling in different cell types during leukemogenesis.Semantic proximity Read ↗

RAS mutations in myeloid malignancies: revisiting old questions with novel insights and therapeutic perspectives.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.