Article
The TrkAIII oncoprotein inhibits mitochondrial free radical ROS-induced death of SH-SY5Y neuroblastoma cells by augmenting SOD2 expression and activity at the mitochondria, within the context of a tumour stem cell-like phenotype.
PloS one - 1 Jan 2014
Ruggeri Pierdomenico, Farina Antonietta R, Di Ianni Natalia, Cappabianca Lucia, Ragone Marzia, Ianni Giulia, Gulino Alberto, Mackay Andrew R
Abstract excerpt
The developmental and stress-regulated alternative TrkAIII splice variant of the NGF receptor TrkA is expressed by advanced stage human neuroblastomas (NBs), correlates with worse outcome in high TrkA expressing unfavourable tumours and exhibits oncogenic activity in NB models. In the present study, we report that constitutive TrkAIII expression in human SH-SY5Y NB cells inhibits Rotenone, Paraquat and...
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