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Article

Fas/Fas ligand regulation mediates cell death in human Ewing's sarcoma cells treated with melatonin

1 Mar 2012

Abstract excerpt

BACKGROUND: Despite recent advances in cancer therapy, the 5-year survival rate for Ewing's sarcoma is still very low, and new therapeutic approaches are necessary. It was found previously that melatonin induces cell death in the Ewing's sarcoma cell line, SK-N-MC, by activating the extrinsic apoptotic pathway. METHODS: Melatonin actions were analysed by metabolic viability/survival cell assays, flow cytometry,...

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PMID: 22382690
DOI: 10.1038/bjc.2012.66

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