Changes in Cell Cycle and Up-Regulation of Neuronal Markers During SH-SY5Y Neurodifferentiation by Retinoic Acid are Mediated by Reactive Species Production and Oxidative Stress.

doi:10.1007/s12035-016-0189-4

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Changes in Cell Cycle and Up-Regulation of Neuronal Markers During SH-SY5Y Neurodifferentiation by Retinoic Acid are Mediated by Reactive Species Production and Oxidative Stress.

Molecular neurobiology - 1 Nov 2017

Kunzler Alice, Zeidán-Chuliá Fares, Gasparotto Juciano, Girardi Carolina Saibro, Klafke Karina, Petiz Lyvia Lintzmaier, Bortolin Rafael Calixto, Rostirolla Diana Carolina, Zanotto-Filho Alfeu, de Bittencourt Pasquali Matheus Augusto, Dickson Phillip, Dunkley Peter, Moreira José Cláudio Fonseca, Gelain Daniel Pens

Abstract excerpt

Human neuroblastoma SH-SY5Y cells have been used as an in vitro model for neurodegenerative disorders such as Parkinson's disease and can be induced to a mature neuronal phenotype through retinoic acid (RA) differentiation. However, mechanisms of RA-induced differentiation remain unclear. Here, we investigate the role of reactive species (RS) on SH-SY5Y neuroblastoma cells under RA differentiation, using the...

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PMID: 27771902
DOI: 10.1007/s12035-016-0189-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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