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Article

Aberrant splicing of the <scp>DMP1</scp>‐<scp>ARF</scp>‐<scp>MDM2</scp>‐p53 pathway in cancer

23 Jan 2016

Abstract excerpt

Alternative splicing (AS) of mRNA precursors is a ubiquitous mechanism for generating numerous transcripts with different activities from one genomic locus in mammalian cells. The gene products from a single locus can thus have similar, dominant-negative or even opposing functions. Aberrant AS has been found in cancer to express proteins that promote cell growth, local invasion and metastasis. This review will...

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PMID: 26802432
DOI: 10.1002/ijc.30003

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