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Article

Multiple components of the spliceosome regulate Mcl1 activity in neuroblastoma

20 Feb 2014

Abstract excerpt

Cancer treatments induce cell stress to trigger apoptosis in tumor cells. Many cancers repress these apoptotic signals through alterations in the Bcl2 proteins that regulate this process. Therapeutics that target these specific survival biases are in development, and drugs that inhibit Bcl2 activities have shown clinical activity for some cancers. Mcl1 is a survival factor for which no effective antagonists have...

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PMID: 24556687
DOI: 10.1038/cddis.2014.40

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