Article
A novel mutation in the miR-128b gene reduces miRNA processing and leads to glucocorticoid resistance of MLL-AF4 acute lymphocytic leukemia cells.
Cell cycle (Georgetown, Tex.) - 15 Mar 2010
Kotani Ai, Ha Daon, Schotte Diana, den Boer Monique L, Armstrong Scott A, Lodish Harvey F
Abstract excerpt
MLL-AF4 acute lymphocytic leukemia has a poor prognosis, and the mechanisms by which these leukemias develop are not understood despite intensive research based on well-known concepts and methods. MicroRNAs (miRNAs) are a new class of small noncoding RNAs that post-transcriptionally regulate expression of target mRNA transcripts. We recently reported that ectopic expression of miR-128b together with miR-221, two...
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