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Article

MicroRNA-125b transforms myeloid cell lines by repressing multiple mRNA

11 Jun 2012

Abstract excerpt

BACKGROUND: We previously described a t(2;11)(p21;q23) chromosomal translocation found in patients with myelodysplasia or acute myeloid leukemia that leads to over-expression of the microRNA miR-125b, and we showed that transplantation of mice with murine stem/progenitor cells overexpressing miR-125b is able to induce leukemia. In this study, we investigated the mechanism of myeloid transformation by miR-125b....

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PMID: 22689670
DOI: 10.3324/haematol.2011.061515

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