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Article

Estimation of effect size distribution from genome-wide association studies and implications for future discoveries.

Nature genetics - 1 Jul 2010

Park Ju-Hyun, Wacholder Sholom, Gail Mitchell H, Peters Ulrike, Jacobs Kevin B, Chanock Stephen J, Chatterjee Nilanjan

Abstract excerpt

We report a set of tools to estimate the number of susceptibility loci and the distribution of their effect sizes for a trait on the basis of discoveries from existing genome-wide association studies (GWASs). We propose statistical power calculations for future GWASs using estimated distributions of effect sizes. Using reported GWAS findings for height, Crohn's disease and breast, prostate and colorectal (BPC)...

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Identifiers

PMID: 20562874
DOI: 10.1038/ng.610
PMCID: PMC4615599

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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