Article
Evidence for an inflammatory bowel disease locus on chromosome 3p26: linkage, transmission/disequilibrium and partitioning of linkage.
Human molecular genetics - 1 Oct 2002
Duerr Richard H, Barmada M Michael, Zhang Leilei, Achkar Jean-Paul, Cho Judy H, Hanauer Stephen B, Brant Steven R, Bayless Theodore M, Baldassano Robert N, Weeks Daniel E
Abstract excerpt
Crohn's disease and ulcerative colitis, the two major forms of idiopathic inflammatory bowel disease (IBD), are heritable, complex traits that appear to share some but not all susceptibility loci. We report that transmission/disequilibrium test analysis of a Crohn's disease genome scan dataset has detected an inflammatory bowel disease locus on chromosome 3p26 (nominal P=0.000052 and genome-wide corrected P=0.039...
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