Article
A hybrid qPCR/SNP array approach allows cost efficient assessment of KIR gene copy numbers in large samples.
BMC genomics - 11 Apr 2014
Pontikos Nikolas, Smyth Deborah J, Schuilenburg Helen, Howson Joanna M M, Walker Neil M, Burren Oliver S, Guo Hui, Onengut-Gumuscu Suna, Chen Wei-Min, Concannon Patrick, Rich Stephen S, Jayaraman Jyothi, Jiang Wei, Traherne James A, Trowsdale John, Todd John A, Wallace Chris
Abstract excerpt
BACKGROUND: Killer Immunoglobulin-like Receptors (KIRs) are surface receptors of natural killer cells that bind to their corresponding Human Leukocyte Antigen (HLA) class I ligands, making them interesting candidate genes for HLA-associated autoimmune diseases, including type 1 diabetes (T1D). However, allelic and copy number variation in the KIR region effectively mask it from standard genome-wide association...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.