Article
An empirical comparison of meta-analysis and mega-analysis of individual participant data for identifying gene-environment interactions.
Genetic epidemiology - 1 May 2014
Sung Yun Ju, Schwander Karen, Arnett Donna K, Kardia Sharon L R, Rankinen Tuomo, Bouchard Claude, Boerwinkle Eric, Hunt Steven C, Rao Dabeeru C
Abstract excerpt
For analysis of the main effects of SNPs, meta-analysis of summary results from individual studies has been shown to provide comparable results as "mega-analysis" that jointly analyzes the pooled participant data from the available studies. This fact revolutionized the genetic analysis of complex traits through large GWAS consortia. Investigations of gene-environment (G×E) interactions are on the rise since they...
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