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Meta-Analysis of Joint Test of SNP and SNP-Environment Interaction with Heterogeneity.

Human heredity - 1 Jan 2021

Jin Qinqin, Shi Gang

Abstract excerpt

Many complex diseases are caused by single nucleotide polymorphisms (SNPs), environmental factors, and the interaction between SNPs and environment. Joint tests of the SNP and SNP-environment interaction effects (JMA) and meta-regression (MR) are commonly used to evaluate these SNP-environment interactions. However, these two methods do not consider genetic heterogeneity. We previously presented a random-effect...

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PMID: 34700323
DOI: 10.1159/000519098

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