Article
On meta- and mega-analyses for gene-environment interactions.
Genetic epidemiology - 1 Dec 2017
Huang Jing, Liu Yulun, Vitale Steve, Penning Trevor M, Whitehead Alexander S, Blair Ian A, Vachani Anil, Clapper Margie L, Muscat Joshua E, Lazarus Philip, Scheet Paul, Moore Jason H, Chen Yong
Abstract excerpt
Gene-by-environment (G × E) interactions are important in explaining the missing heritability and understanding the causation of complex diseases, but a single, moderately sized study often has limited statistical power to detect such interactions. With the increasing need for integrating data and reporting results from multiple collaborative studies or sites, debate over choice between mega- versus meta-analysis...
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