Article

Soluble Endoglin Stimulates Inflammatory and Angiogenic Responses in Microglia That Are Associated with Endothelial Dysfunction

2022-01-06

Abstract excerpt

Increased soluble endoglin (sENG) were observed in human brain arteriovenous malformations (bAVMs), and overexpression of sENG with vascular endothelial growth factor (VEGF)-A induced dysplastic vessel formation in mouse brain. However, the underlying mechanism of sENG-induced vascular malformations is not clear. While evidence suggests the role of sENG as a pro-inflammatory modulator, increased microglial accumul...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f525c999-854d-58cc-abd8-50384e139fce
DOI: 10.20944/preprints202201.0096.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Soluble Endoglin Stimulates Inflammatory and Angiogenic Responses in Microglia That Are Associated with Endothelial DysfunctionDOI 10.20944/preprints202201.0096.v1Read

Neuroinflammation Plays a Critical Role in Cerebral Cavernous Malformation DiseaseSemantic proximity Read

Biology of cerebral arteriovenous malformations with a focus on inflammation.Semantic proximity Read

Neuroinflammation plays a critical role in cerebral cavernous malformation diseaseSemantic proximity Read

Juxtacrine DLL4-NOTCH1 signaling between astrocytes drives neuroinflammation via the IL-6-STAT3 axisSemantic proximity Read

Brain Injury: Response to Injury Wound Healing Mechanisms and Enlarged Perivascular Spaces in Obesity, Metabolic Syndrome, and Type 2 Diabetes MellitusSemantic proximity Read

Transcriptomic signatures of individual cell types in cerebral cavernous malformationSemantic proximity Read

Endothelial dysfunction in neurodegenerative disease: Is endothelial inflammation an overlooked druggable target?Semantic proximity Read

Endothelial oncogenic KRAS mutation drives the dynamics of microglia and macrophages in brain arteriovenous malformation.Semantic proximity Read

Mutant KRAS in brain endothelial cells promotes vascular inflammation and impairs vascular integrity in brain arteriovenous malformation.Semantic proximity Read

Astrocytic DLL4-NOTCH1 signaling pathway promotes neuroinflammation via the IL-6-STAT3 axisSemantic proximity Read

Deciphering perivascular macrophages and microglia in the retinal ganglion cell layersSemantic proximity Read

Astrocytes propel neurovascular dysfunction during cerebral cavernous malformation lesion formation.Semantic proximity Read