Article

Proof-of-Concept in a Murine Model of Treatment of Thrombotic Thrombocytopenic Purpura Using Engineered Red Blood Cells

2025-06-15

Abstract excerpt

Thrombotic Thrombocytopenic Purpura (TTP) is caused by congenital or acquired deficiency of ADAMTS13, a metalloproteinase that cleaves von Willebrand Factor (vWF) multimers. Current treatments—plasma exchange and immunosuppression—are costly and associated with significant morbidity therefore, alternative strategies are needed. We developed the kitJak2 platform for producing genetically engineered lab-grown red bl...

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Literature Corpus work: ffebe426-b572-5db8-999c-09dc43ab6422
DOI: 10.1101/2025.06.12.659386

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