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Article

Impact on replicative fitness of the G48E substitution in the protease of HIV-1: an in vitro and in silico evaluation.

Journal of acquired immune deficiency syndromes (1999) - 1 Jul 2008

Zimmer Jean-Marie, Roman François, Lambert Christine, Jonckheer Abel, Vazquez Ana, Plesséria Jean-Marc, Servais Jean-Yves, Covens Kris, Weber Jan, Van Laethem Kristel, Schmit Jean-Claude, Vandamme Anne-Mieke, Quinones-Mateu Miguel E, De Maeyer Marc

Abstract excerpt

We observed an unusual glycine-to-glutamate substitution at protease (PR) residue position 48 (G48E) in an African patient infected with a subtype A1 HIV-1 strain failing a saquinavir-containing regimen. Phenotypic analysis of protease inhibitor (PI) susceptibility showed that the G48E site-direc...

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Identifiers

PMID: 18545158
DOI: 10.1097/QAI.0b013e318174dca6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18545158-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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