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Article

Impact of a Met(11)Thr single nucleotide polymorphism of surfactant protein D on allergic airway inflammation in a murine asthma model.

Experimental lung research - 1 Apr 2014

Winkler Carla, Bahlmann Olaf, Viereck Janika, Knudsen Lars, Wedekind Dirk, Hoymann Heinz Gerd, Madsen Jens, Thum Thomas, Hohlfeld Jens M, Ochs Matthias

Abstract excerpt

The surfactant-associated proteins SP-A and D are pattern recognition molecules with collectin structure. A single nucleotide polymorphism (SNP) exchanging a methionine (Met) for a threonine (Thr) in the amino-terminal SP-D domain influences the oligomeric structure and function of the protein. In this study, we investigated the susceptibility of mice transgenic for the human SP-D Met(11)Thr SNP to allergic...

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PMID: 24712849
DOI: 10.3109/01902148.2014.891062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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