Article
Specificity of the transport of lipid II by FtsW in Escherichia coli.
The Journal of biological chemistry - 23 May 2014
Mohammadi Tamimount, Sijbrandi Robert, Lutters Mandy, Verheul Jolanda, Martin Nathaniel I, den Blaauwen Tanneke, de Kruijff Ben, Breukink Eefjan
Abstract excerpt
Synthesis of biogenic membranes requires transbilayer movement of lipid-linked sugar molecules. This biological process, which is fundamental in prokaryotic cells, remains as yet not clearly understood. In order to obtain insights into the molecular basis of its mode of action, we analyzed the structure-function relationship between Lipid II, the important building block of the bacterial cell wall, and its inner...
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