Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Its own architect: Flipping cardiolipin synthase.

Science advances - 3 Jan 2025

Sawasato Katsuhiro, Dowhan William, Bogdanov Mikhail

Abstract excerpt

Current dogma assumes that lipid asymmetry in biological membranes is actively maintained and dispensable for cell viability. The inner (cytoplasmic) membrane (IM) of Escherichia coli is asymmetric. However, the molecular mechanism that maintains this uneven distribution is unknown. We engineered a conditionally lethal phosphatidylethanolamine (PE)-deficient mutant in which the presence of cardiolipin (CL) on the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiolipins
Share to Cell Membrane
Share to Escherichia coli

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Escherichia coli Proteins

Share to Membrane Proteins

Share to Mutation

Share to Phosphatidylethanolamines

Share to Transferases (Other Substituted Phosphate Groups)

Source

Open in PubMed Open full text

Identifiers

PMID: 39752486
DOI: 10.1126/sciadv.ads0244
PMCID: PMC11698083

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Its own architect: Flipping cardiolipin synthase.PMID 39752486Read ↗

Disruption of lipid homeostasis in the Gram-negative cell envelope activates a novel cell death pathway.Semantic proximity Read ↗

Lipid-engineered Escherichia coli membranes reveal critical lipid headgroup size for protein function.Semantic proximity Read ↗

Discovery of a cardiolipin synthase utilizing phosphatidylethanolamine and phosphatidylglycerol as substrates.Semantic proximity Read ↗

Structure of a proton-dependent lipid transporter involved in lipoteichoic acids biosynthesis.Semantic proximity Read ↗

Checkpoints That Regulate Balanced Biosynthesis of Lipopolysaccharide and Its Essentiality in Escherichia coli.Semantic proximity Read ↗

Substrate Selectivity of Lysophospholipid Transporter LplT Involved in Membrane Phospholipid Remodeling in Escherichia coli.Semantic proximity Read ↗

On the track of the lipid transport pathway of the phospholipid flippase ATP8A2 - Mutation analysis of residues of the transmembrane segments M1, M2, M3 and M4.Semantic proximity Read ↗

Monoglucosyldiacylglycerol, a foreign lipid, can substitute for phosphatidylethanolamine in essential membrane-associated functions in Escherichia coli.Semantic proximity Read ↗

Cardiolipin is required in vivo for the stability of bacterial translocon and optimal membrane protein translocation and insertion.Semantic proximity Read ↗

MsbA-dependent translocation of lipids across the inner membrane of Escherichia coli.Semantic proximity Read ↗

Phosphatidic acid and N-acylphosphatidylethanolamine form membrane domains in Escherichia coli mutant lacking cardiolipin and phosphatidylglycerol.Semantic proximity Read ↗

Plasticity within the barrel domain of BamA mediates a hybrid-barrel mechanism by BAM.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.