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Article

Structure and mutagenic analysis of the lipid II flippase MurJ from Escherichia coli.

Proceedings of the National Academy of Sciences of the United States of America - 26 Jun 2018

Zheng Sanduo, Sham Lok-To, Rubino Frederick A, Brock Kelly P, Robins William P, Mekalanos John J, Marks Debora S, Bernhardt Thomas G, Kruse Andrew C

Abstract excerpt

The peptidoglycan cell wall provides an essential protective barrier in almost all bacteria, defining cellular morphology and conferring resistance to osmotic stress and other environmental hazards. The precursor to peptidoglycan, lipid II, is assembled on the inner leaflet of the plasma membrane. However, peptidoglycan polymerization occurs on the outer face of the plasma membrane, and lipid II must be flipped...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29891673
DOI: 10.1073/pnas.1802192115
PMCID: PMC6042122

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Structure and mutagenic analysis of the lipid II flippase MurJ from Escherichia coli.PMID 29891673Read ↗

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