Article
Analysis of the expression of candidate genes for type 1 diabetes susceptibility in T cells.
Endocrine journal - 1 Jan 2014
Hisanaga-Oishi Yuko, Nishiwaki-Ueda Yumiko, Nojima Koji, Ueda Hironori
Abstract excerpt
Type 1 diabetes is characterized by T-cell-mediated autoimmune destruction of pancreatic β-cells. Currently, approximately 50 type 1 diabetes susceptibility genes or chromosomal regions have been identified. However, the functions of type 1 diabetes susceptibility genes in T cells are elusive. In this study, we evaluated the correlation between type 1 diabetes susceptibility genes and T-cell signaling. The...
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