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Article

Heterogeneity of signal transduction by Na-K-ATPase α-isoforms: role of Src interaction.

American journal of physiology. Cell physiology - 1 Feb 2018

Yu Hui, Cui Xiaoyu, Zhang Jue, Xie Joe X, Banerjee Moumita, Pierre Sandrine V, Xie Zijian

Abstract excerpt

Of the four Na-K-ATPase α-isoforms, the ubiquitous α1 Na-K-ATPase possesses both ion transport and Src-dependent signaling functions. Mechanistically, we have identified two putative pairs of domain interactions between α1 Na-K-ATPase and Src that are critical for α1 signaling function. Our subsequent report that α2 Na-K-ATPase lacks these putative Src-binding sites and fails to carry on Src-dependent signaling...

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Identifiers

PMID: 29118027
DOI: 10.1152/ajpcell.00124.2017
PMCID: PMC5866435

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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