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Article

Tyrosine kinase signal modulation: a matter of H2O2 membrane permeability?

Antioxidants & redox signaling - 1 Nov 2013

Bertolotti Milena, Bestetti Stefano, García-Manteiga Jose M, Medraño-Fernandez Iria, Dal Mas Andrea, Malosio Maria Luisa, Sitia Roberto

Abstract excerpt

Abstract H2O2 produced by extracellular NADPH oxidases regulates tyrosine kinase signaling inhibiting phosphatases. How does it cross the membrane to reach its cytosolic targets? Silencing aquaporin-8 (AQP8), but not AQP3 or AQP4, inhibited H2O2 entry into HeLa cells. Re-expression of AQP8 with silencing-resistant vectors rescued H2O2 transport, whereas a C173A-AQP8 mutant failed to do so. Lowering AQP8 levels...

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Source

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Identifiers

PMID: 23541115
DOI: 10.1089/ars.2013.5330
PMCID: PMC3797449

Genes

AQP8
AQP3
AQP4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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