Endothelin-1 aggravates hypoxia/reoxygenation-induced injury in renal epithelial cells through the activation of a Na+/Ca2+ exchanger.

doi:10.1097/01.fjc.0000166313.61129.3a

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Article

Endothelin-1 aggravates hypoxia/reoxygenation-induced injury in renal epithelial cells through the activation of a Na+/Ca2+ exchanger.

Journal of cardiovascular pharmacology - 1 Nov 2004

Iwamoto Takahiro, Kita Satomi, Katsuragi Takeshi

Abstract excerpt

We analyzed the role of the Na/Ca2+ exchanger (NCX) in hypoxia/reoxygenation-induced injury and also its interaction with endothelin-1 in the proximal epithelial cell line LLC-PK1. The hypoxia/reoxygenation protocol caused a significant leakage of lactate dehydrogenase from parental LLC-PK1 cells, which was markedly suppressed by KB-R7943, a selective NCX inhibitor. Overexpression of wild-type NCX1 into LLC-PK1...

Topics

Animals
Calcium
Cell Hypoxia
Cell Survival
Dogs
Dose-Response Relationship, Drug
Endothelin-1
Epithelial Cells
Kidney
LLC-PK1 Cells
Mutation
Reperfusion Injury
Sodium-Calcium Exchanger
Swine
Thiourea
Transfection

Source

Open in PubMed

Identifiers

PMID: 15838349
DOI: 10.1097/01.fjc.0000166313.61129.3a

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