Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endothelin-1 aggravates hypoxia/reoxygenation-induced injury in renal epithelial cells through the activation of a Na+/Ca2+ exchanger.

Journal of cardiovascular pharmacology - 1 Nov 2004

Iwamoto Takahiro, Kita Satomi, Katsuragi Takeshi

Abstract excerpt

We analyzed the role of the Na/Ca2+ exchanger (NCX) in hypoxia/reoxygenation-induced injury and also its interaction with endothelin-1 in the proximal epithelial cell line LLC-PK1. The hypoxia/reoxygenation protocol caused a significant leakage of lactate dehydrogenase from parental LLC-PK1 cells, which was markedly suppressed by KB-R7943, a selective NCX inhibitor. Overexpression of wild-type NCX1 into LLC-PK1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium
Share to Cell Hypoxia
Share to Dogs

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Endothelin-1

Share to Epithelial Cells

Share to Kidney

Share to Reperfusion Injury

Share to Sodium-Calcium Exchanger

Source

Identifiers

PMID: 15838349
DOI: 10.1097/01.fjc.0000166313.61129.3a

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endothelin-1 aggravates hypoxia/reoxygenation-induced injury in renal epithelial cells through the activation of a Na+/Ca2+ exchanger.PMID 15838349Read ↗

Endothelin-1 enhances the activity of Na+/Ca2+ exchanger type 1 in renal epithelial cells.Semantic proximity Read ↗

The mitochondrial Na <sup>+</sup> /Ca <sup>2+</sup> exchanger NCLX is implied in the activation of hypoxia-inducible factorsSemantic proximity Read ↗

Hypoxia-induced endocytosis of Na,K-ATPase in alveolar epithelial cells is mediated by mitochondrial reactive oxygen species and PKC-zeta.Semantic proximity Read ↗

The Na+/Ca2+ Exchanger 1 (NCX1) Variant 3 as the Major Extrusion System in Renal Distal Tubular Transcellular Ca2+-Transport.Semantic proximity Read ↗

Involvement of Na/K-ATPase in hydrogen peroxide-induced activation of the Src/ERK pathway in LLC-PK1 cells.Semantic proximity Read ↗

Endothelin receptor-specific control of endoplasmic reticulum stress and apoptosis in the kidneySemantic proximity Read ↗

Involvement of the Na+/Ca2+ exchanger isoform 1 (NCX1) in neuronal growth factor (NGF)-induced neuronal differentiation through Ca2+-dependent Akt phosphorylation.Semantic proximity Read ↗

Different cation sensitivities and binding site domains of Na+-Ca2+-K+ and Na+-Ca2+ exchangers.Semantic proximity Read ↗

Transient expression of Na+/H+ exchanger isoform NHE-2 in LLC-PK1 cells: inhibition of endogenous NHE-3 and regulation by hypertonicity.Semantic proximity Read ↗

Reduced glutathione protect cells from ouabain toxicity.Semantic proximity Read ↗

Effect of overexpression of the brain-specific Na(+)/Ca(2+) exchanger splice variant NCX1.5 on NO cytotoxicity in HEK293 cells.Semantic proximity Read ↗

The two isoforms of the Na+/Ca2+ exchanger, NCX1 and NCX3, constitute novel additional targets for the prosurvival action of Akt/protein kinase B pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.