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Article

Expression of mutant α1 Na/K-ATPase defective in conformational transition attenuates Src-mediated signal transduction.

The Journal of biological chemistry - 22 Feb 2013

Ye Qiqi, Lai Fangfang, Banerjee Moumita, Duan Qiming, Li Zhichuan, Si Shuyi, Xie Zijian

Abstract excerpt

The α1 Na/K-ATPase possesses both pumping and signaling functions. Using purified enzyme we found that the α1 Na/K-ATPase might interact with and regulate Src activity in a conformation-dependent manner. Here we further explored the importance of the conformational transition capability of α1 Na/K-ATPase in regulation of Src-related signal transduction in cell culture. We first rescued the α1-knockdown cells by...

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Identifiers

PMID: 23288841
DOI: 10.1074/jbc.M112.442608
PMCID: PMC3581412

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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