Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Amino acid residues required for Gtr1p-Gtr2p complex formation and its interactions with the Ego1p-Ego3p complex and TORC1 components in yeast.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Jun 2014

Sekiguchi Takeshi, Kamada Yoshiaki, Furuno Nobuaki, Funakoshi Minoru, Kobayashi Hideki

Abstract excerpt

The yeast Ras-like GTPases Gtr1p and Gtr2p form a heterodimer, are implicated in the regulation of TOR complex 1 (TORC1) and play pivotal roles in cell growth. Gtr1p and Gtr2p bind Ego1p and Ego3p, which are tethered to the endosomal and vacuolar membranes where TORC1 functions are regulated through a relay of amino acid signaling interactions. The mechanisms by which Gtr1p and Gtr2p activate TORC1 remain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acids
Share to Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Monomeric GTP-Binding Proteins

Share to Mutation

Share to Protein Multimerization

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Share to Transcription Factors

Source

Identifiers

PMID: 24702707
DOI: 10.1111/gtc.12145

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Amino acid residues required for Gtr1p-Gtr2p complex formation and its interactions with the Ego1p-Ego3p complex and TORC1 components in yeast.PMID 24702707Read ↗

Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation.Semantic proximity Read ↗

Endolysosomal membrane trafficking complexes drive nutrient-dependent TORC1 signaling to control cell growth in Saccharomyces cerevisiae.Semantic proximity Read ↗

The Vam6 GEF controls TORC1 by activating the EGO complex.Semantic proximity Read ↗

TORC1 signaling is governed by two negative regulators in fission yeast.Semantic proximity Read ↗

LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway.Semantic proximity Read ↗

A component of the TOR (Target Of Rapamycin) nutrient-sensing pathway plays a role in circadian rhythmicity in Neurospora crassa.Semantic proximity Read ↗

Molecular interactions of yeast Neo1p, an essential member of the Drs2 family of aminophospholipid translocases, and its role in membrane trafficking within the endomembrane system.Semantic proximity Read ↗

GATA Factor Regulation in Excess Nitrogen Occurs Independently of Gtr-Ego Complex-Dependent TorC1 Activation.Semantic proximity Read ↗

Importance of homodimerization for the in vivo function of yeast RNA triphosphatase.Semantic proximity Read ↗

Separate domains in GCN1 for binding protein kinase GCN2 and ribosomes are required for GCN2 activation in amino acid-starved cells.Semantic proximity Read ↗

Role of the Tsc1-Tsc2 complex in signaling and transport across the cell membrane in the fission yeast Schizosaccharomyces pombe.Semantic proximity Read ↗

Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.