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Article

Endolysosomal membrane trafficking complexes drive nutrient-dependent TORC1 signaling to control cell growth in Saccharomyces cerevisiae.

Genetics - 1 Apr 2014

Kingsbury Joanne M, Sen Neelam D, Maeda Tatsuya, Heitman Joseph, Cardenas Maria E

Abstract excerpt

The rapamycin-sensitive and endomembrane-associated TORC1 pathway controls cell growth in response to nutrients in eukaryotes. Mutations in class C Vps (Vps-C) complexes are synthetically lethal with tor1 mutations and confer rapamycin hypersensitivity in Saccharomyces cerevisiae, suggesting a role for these complexes in TORC1 signaling. Vps-C complexes are required for vesicular trafficking and fusion and...

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Identifiers

PMID: 24514902
DOI: 10.1534/genetics.114.161646
PMCID: PMC3982701

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Endolysosomal membrane trafficking complexes drive nutrient-dependent TORC1 signaling to control cell growth in Saccharomyces cerevisiae.PMID 24514902Read ↗

Efficient Tor signaling requires a functional class C Vps protein complex in Saccharomyces cerevisiae.Semantic proximity Read ↗

Vps-C complexes: gatekeepers of endolysosomal traffic.Semantic proximity Read ↗

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Target of Rapamycin (TOR) Regulates Growth in Response to Nutritional SignalsSemantic proximity Read ↗

Vesicular Trafficking Systems Impact TORC1-Controlled Transcriptional Programs in Saccharomyces cerevisiae.Semantic proximity Read ↗

Target of Rapamycin (TOR) in Nutrient Signaling and Growth ControlSemantic proximity Read ↗

The Vam6 GEF controls TORC1 by activating the EGO complex.Semantic proximity Read ↗

Nuclear translocation of Gln3 in response to nutrient signals requires Golgi-to-endosome trafficking in Saccharomyces cerevisiae.Semantic proximity Read ↗

TOR complex 2 (TORC2) signaling and the ESCRT machinery cooperate in the protection of plasma membrane integrity in yeast.Semantic proximity Read ↗

Identification of TOR signaling complexes: more TORC for the cell growth engine.Semantic proximity Read ↗

Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation.Semantic proximity Read ↗

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