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Article

A component of the TOR (Target Of Rapamycin) nutrient-sensing pathway plays a role in circadian rhythmicity in Neurospora crassa.

PLoS genetics - 1 Jun 2018

Ratnayake Lalanthi, Adhvaryu Keyur K, Kafes Elizabeth, Motavaze Kamyar, Lakin-Thomas Patricia

Abstract excerpt

The TOR (Target of Rapamycin) pathway is a highly-conserved signaling pathway in eukaryotes that regulates cellular growth and stress responses. The cellular response to amino acids or carbon sources such as glucose requires anchoring of the TOR kinase complex to the lysosomal/vacuolar membrane by the Ragulator (mammals) or EGO (yeast) protein complex. Here we report a connection between the TOR pathway and...

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Source

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Identifiers

PMID: 29924817
DOI: 10.1371/journal.pgen.1007457
PMCID: PMC6028147

Genes

LAMTOR1

Provenance

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