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Article

LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway.

The Journal of cell biology - 28 Apr 2003

Chen Esther J, Kaiser Chris A

Abstract excerpt

LST8, a Saccharomyces cerevisiae gene encoding a 34-kD WD-repeat protein, was identified by mutations that caused defects in sorting Gap1p to the plasma membrane. Here, we report that the Gap1p sorting defect in the lst8-1 mutant results from derepression of Rtg1/3p activity and the subsequent accumulation of high levels of intracellular amino acids, which signal Gap1p sorting to the vacuole. To identify the...

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Identifiers

PMID: 12719473
DOI: 10.1083/jcb.200210141
PMCID: PMC2172900

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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