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Article

Release of peptide promoted by the GGQ motif of class 1 release factors regulates the GTPase activity of RF3.

Molecular cell - 1 Oct 2002

Zavialov Andrei V, Mora Liliana, Buckingham Richard H, Ehrenberg Måns

Abstract excerpt

E. coli mutants of RF1 and RF2, in which the universal GGQ motif is changed to GAQ, are slow in peptide release from ribosomes. Other kinetic properties are unchanged, suggesting that the GGQ motif is in contact with the peptidyl-transferase center. Deacylated tRNA terminates protein synthesis codon specifically, indicating that the CCA end of tRNA and the GGQ motif operate similarly. Addition of a mutant factor...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 12419223
DOI: 10.1016/s1097-2765(02)00691-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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