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Article

A novel class of bacterial translation factor RF3 mutations suggests specific structural domains for premature peptidyl-tRNA drop-off.

FEBS letters - 19 Feb 2010

Watanabe Yuya, Nakamura Yoshikazu, Ito Koichi

Abstract excerpt

The bacterial translation factor RF3 promotes translation termination by recycling the tRNA-mimicking release factors, RF1 and RF2, after mature polypeptide release. RF3 also enhances the premature peptidyl-tRNA drop-off reaction in the presence of RRF and EF-G. Despite the recently resolved X-ray crystal structure of RF3, the molecular details of the bimodal functionality of RF3 remain obscure. In this report,...

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PMID: 20043913
DOI: 10.1016/j.febslet.2009.12.048

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A novel class of bacterial translation factor RF3 mutations suggests specific structural domains for premature peptidyl-tRNA drop-off.PMID 20043913Read ↗

Interactions of release factor RF3 with the translation machinery.Semantic proximity Read ↗

RF3 induces ribosomal conformational changes responsible for dissociation of class I release factors.Semantic proximity Read ↗

Ribosome release factor RF4 and termination factor RF3 are involved in dissociation of peptidyl-tRNA from the ribosome.Semantic proximity Read ↗

Release of peptide promoted by the GGQ motif of class 1 release factors regulates the GTPase activity of RF3.Semantic proximity Read ↗

Eukaryotic release factor 3 is required for multiple turnovers of peptide release catalysis by eukaryotic release factor 1.Semantic proximity Read ↗

Evidence for a role of initiation factor 3 in recycling of ribosomal complexes stalled on mRNAs in Escherichia coli.Semantic proximity Read ↗

Stop codon recognition and interactions with peptide release factor RF3 of truncated and chimeric RF1 and RF2 from Escherichia coli.Semantic proximity Read ↗

Release factor RF3 abolishes competition between release factor RF1 and ribosome recycling factor (RRF) for a ribosome binding site.Semantic proximity Read ↗

Mechanism of Translation Termination: RF1 Dissociation Follows Dissociation of RF3 from the Ribosome.Semantic proximity Read ↗

Suppression of temperature-sensitive defects of polypeptide release factors RF-1 and RF-2 by mutations or by an excess of RF-3 in Escherichia coli.Semantic proximity Read ↗

Global analysis of translation termination in E. coli.Semantic proximity Read ↗

R213I mutation in release factor 2 (RF2) is one step forward for engineering an omnipotent release factor in bacteria Escherichia coli.Semantic proximity Read ↗

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