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Article

Reprogramming the Mechanism of Action of Chlorambucil by Coupling to a G-Quadruplex Ligand

3 Apr 2014

Abstract excerpt

The nitrogen mustard Chlorambucil (Chl) generates covalent adducts with double-helical DNA and inhibits cell proliferation. Among these adducts, interstrand cross-links (ICLs) are the most toxic, as they stall replication by generating DNA double strand breaks (DSBs). Conversely, intrastrand cross-links generated by Chl are efficiently repaired by a dedicated Nucleotide Excision Repair (NER) enzyme. We...

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PMID: 24697838
DOI: 10.1021/ja5014344

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