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Article

N 2-Alkyl-dG lesions elicit R-loop accumulation in the genome

1 Oct 2024

Abstract excerpt

Humans are exposed to DNA alkylating agents through endogenous metabolism, environmental exposure and cancer chemotherapy. The resulting alkylated DNA adducts may elicit genome instability by perturbing DNA replication and transcription. R-loops regulate various cellular processes, including transcription, DNA repair, and telomere maintenance. However, unscheduled R-loops are also recognized as potential sources...

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PMID: 39351875
DOI: 10.1093/nar/gkae845

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