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Article

Transformation of the cerebellum into more ventral brainstem fates causes cerebellar agenesis in the absence of Ptf1a function.

Proceedings of the National Academy of Sciences of the United States of America - 29 Apr 2014

Millen Kathleen J, Steshina Ekaterina Y, Iskusnykh Igor Y, Chizhikov Victor V

Abstract excerpt

Model organism studies have demonstrated that cell fate specification decisions play an important role in normal brain development. Their role in human neurodevelopmental disorders, however, is poorly understood, with very few examples described. The cerebellum is an excellent system to study mechanisms of cell fate specification. Although signals from the isthmic organizer are known to specify cerebellar...

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PMID: 24733890
DOI: 10.1073/pnas.1315024111
PMCID: PMC4035921

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