Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibitory and excitatory subtypes of cochlear nucleus neurons are defined by distinct bHLH transcription factors, Ptf1a and Atoh1.

Development (Cambridge, England) - 1 Jun 2009

Fujiyama Tomoyuki, Yamada Mayumi, Terao Mami, Terashima Toshio, Hioki Hiroyuki, Inoue Yukiko U, Inoue Takayoshi, Masuyama Norihisa, Obata Kunihiko, Yanagawa Yuchio, Kawaguchi Yoshiya, Nabeshima Yo-Ichi, Hoshino Mikio

Abstract excerpt

The cochlear nucleus (CN), which consists of dorsal and ventral cochlear nuclei (DCN and VCN), plays pivotal roles in processing and relaying auditory information to the brain. Although it contains various types of neurons, the origins of the distinct subtypes and their developmental molecular machinery are still elusive. Here we reveal that two basic helix-loop-helix transcription factors play crucial roles in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic Helix-Loop-Helix Transcription Factors
Share to Cell Differentiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Lineage

Share to Epithelium

Share to Neurogenesis

Share to Neurons

Share to Rhombencephalon

Share to Transcription Factors

Source

Identifiers

PMID: 19439493
DOI: 10.1242/dev.033480

Genes

DCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibitory and excitatory subtypes of cochlear nucleus neurons are defined by distinct bHLH transcription factors, Ptf1a and Atoh1.PMID 19439493Read ↗

Bhlhb5::flpo allele uncovers a requirement for Bhlhb5 for the development of the dorsal cochlear nucleus.Semantic proximity Read ↗

Specification of spatial identities of cerebellar neuron progenitors by ptf1a and atoh1 for proper production of GABAergic and glutamatergic neurons.Semantic proximity Read ↗

An Lmx1a/b allelic series reveals the role of Lmx1 genes in cochlear nuclei development.Semantic proximity Read ↗

Generation and characterization of Atoh1-Cre knock-in mouse line.Semantic proximity Read ↗

Molecular Aspects of the Development and Function of Auditory Neurons.Semantic proximity Read ↗

Selection of cell fate in the organ of Corti involves the integration of Hes/Hey signaling at the Atoh1 promoter.Semantic proximity Read ↗

Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum.Semantic proximity Read ↗

Chromatin remodeling protein CHD4 regulates axon guidance of spiral ganglion neurons in the developing cochleaSemantic proximity Read ↗

Zebrafish atoh1 genes: classic proneural activity in the inner ear and regulation by Fgf and Notch.Semantic proximity Read ↗

The ATP-dependent chromatin remodeling enzyme CHD7 regulates pro-neural gene expression and neurogenesis in the inner earSemantic proximity Read ↗

Lmx1a is required for segregation of sensory epithelia and normal ear histogenesis and morphogenesis.Semantic proximity Read ↗

Conditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.