Article
Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex.
Proceedings of the National Academy of Sciences of the United States of America - 20 Jul 2010
Bedogni Francesco, Hodge Rebecca D, Elsen Gina E, Nelson Branden R, Daza Ray A M, Beyer Richard P, Bammler Theo K, Rubenstein John L R, Hevner Robert F
Abstract excerpt
Areas and layers of the cerebral cortex are specified by genetic programs that are initiated in progenitor cells and then, implemented in postmitotic neurons. Here, we report that Tbr1, a transcription factor expressed in postmitotic projection neurons, exerts positive and negative control over both regional (areal) and laminar identity. Tbr1 null mice exhibited profound defects of frontal cortex and layer 6...
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