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In vivo DNA replication dynamics unveil aging-dependent replication stress

17 Sept 2024

Abstract excerpt

The genome duplication program is affected by multiple factors in vivo, including developmental cues, genotoxic stress, and aging. Here, we monitored DNA replication initiation dynamics in regenerating livers of young and old mice after partial hepatectomy to investigate the impact of aging. In young mice, the origin firing sites were well defined; the majority were located 10-50 kb upstream or downstream of...

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PMID: 39293447
DOI: 10.1016/j.cell.2024.08.034

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