Article
Loss of function tp53 mutations do not accelerate the onset of myc-induced T-cell acute lymphoblastic leukaemia in the zebrafish.
British journal of haematology - 1 Jul 2014
Gutierrez Alejandro, Feng Hui, Stevenson Kristen, Neuberg Donna S, Calzada Oscar, Zhou Yi, Langenau David M, Look A Thomas
Abstract excerpt
The TP53 tumour suppressor is activated in response to distinct stimuli, including an ARF-dependent response to oncogene stress and an ATM/ATR-dependent response to DNA damage. In human T-cell acute lymphoblastic leukaemia (T-ALL), TP53-dependent tumour suppression is typically disabled via biallelic ARF deletions. In murine models, loss of Arf (Cdkn2a) or Tp53 markedly accelerates the onset of Myc-induced...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.