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Article

Clavulanic acid production by the MMS 150 mutant obtained from wild type Streptomyces clavuligerus ATCC 27064.

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] - 1 Dec 2013

da Silva Vasconcelos Eliton, de Lima Vanderlei Aparecido, Goto Leandro Seiji, Cruz-Hernández Isara Lourdes, Hokka Carlos Osamu

Abstract excerpt

Clavulanic acid (CA) is a powerful inhibitor of the beta-lactamases, enzymes produced by bacteria resistants to penicillin and cefalosporin. This molecule is produced industrially by strains of Streptomyces clavuligerus in complex media which carbon and nitrogen resources are supplied by inexpensive compounds still providing high productivity. The genetic production improvement using physical and chemical...

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Identifiers

PMID: 24688492
DOI: 10.1590/S1517-83822014005000005
PMCID: PMC3958168

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