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Article

Genomic Diversity of Streptomyces clavuligerus: Implications for Clavulanic Acid Biosynthesis and Industrial Hyperproduction.

International journal of molecular sciences - 12 Oct 2024

Ríos-Fernández Paula, Caicedo-Montoya Carlos, Ríos-Estepa Rigoberto

Abstract excerpt

Streptomyces clavuligerus is a species used worldwide to industrially produce clavulanic acid (CA), a molecule that enhances antibiotic effectiveness against β-lactamase-producing bacterial strains. Despite its low inherent CA production, hyper-producing strains have been developed. However, genomic analyses specific to S. clavuligerus and CA biosynthesis are limited. Genomic variations that may influence CA...

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Identifiers

PMID: 39456781
DOI: 10.3390/ijms252010992
PMCID: PMC11507055

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