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Article

5S clavam biosynthesis is controlled by an atypical two-component regulatory system in Streptomyces clavuligerus.

Antimicrobial agents and chemotherapy - 1 Sept 2012

Kwong Thomas, Zelyas Nathan J, Cai Hui, Tahlan Kapil, Wong Annie, Jensen Susan E

Abstract excerpt

Streptomyces clavuligerus produces a collection of five clavam metabolites, including the clinically important β-lactamase inhibitor clavulanic acid, as well as four structurally related metabolites called 5S clavams. The paralogue gene cluster of S. clavuligerus is one of three clusters of genes for the production of these clavam metabolites. A region downstream of the cluster was analyzed, and snk, res1, and...

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Identifiers

PMID: 22751548
DOI: 10.1128/AAC.01090-12
PMCID: PMC3421899

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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5S clavam biosynthesis is controlled by an atypical two-component regulatory system in Streptomyces clavuligerus.PMID 22751548Read ↗

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