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Article

Five additional genes are involved in clavulanic acid biosynthesis in Streptomyces clavuligerus.

Antimicrobial agents and chemotherapy - 1 Jan 2004

Jensen S E, Paradkar A S, Mosher R H, Anders C, Beatty P H, Brumlik M J, Griffin A, Barton B

Abstract excerpt

An approximately 12.5-kbp region of DNA sequence from beyond the end of the previously described clavulanic acid gene cluster was analyzed and found to encode nine possible open reading frames (ORFs). Involvement of these ORFs in clavulanic acid biosynthesis was assessed by creating mutants with defects in each of the ORFs. orf12 and orf14 had been previously reported to be involved in clavulanic acid...

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Identifiers

PMID: 14693539
DOI: 10.1128/AAC.48.1.192-202.2004
PMCID: PMC310172

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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