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Article

An approach to strain improvement and enhanced production of clavulanic acid in Streptomyces clavuligerus.

Bioscience, biotechnology, and biochemistry - 1 Jan 2009

Kim Sae-Jin, Kim Jin-Oh, Shin Chang-Hun, Park Hye Won, Kim Chan-Wha

Abstract excerpt

To develop a strategy for improved production of clavulanic acid (CA), we investigated the effect of using oils on cell growth and CA production during the fermentation of Streptomyces clavuligerus NRRL 3585. In this analysis, triolein, whose fatty acid is oleic acid only, was the best oil source for CA production, but free fatty acids generated from the hydrolysis of oils in a culture broth negatively impacted...

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PMID: 19129630
DOI: 10.1271/bbb.80569

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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