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Article

Improvement for the production of clavulanic acid by mutant Streptomyces clavuligerus.

Letters in applied microbiology - 1 Jan 2002

Lee S D, Park S W, Oh K K, Hong S I, Kim S W

Abstract excerpt

AIMS: To improve the production of clavulanic acid through the development of strains, the selection of a production medium and a pH shift strategy in a bioreactor. METHODS AND RESULTS: Streptomyces clavuligerus mutant 15 was selected by antibacterial activities. As a result of pH control in a 2.5 l bioreactor, the highest productivity (3.37 microg x ml(-1) x h(-1)) was obtained at a controlled pH of 7.0....

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PMID: 11967061
DOI: 10.1046/j.1472-765x.2002.01102.x

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