Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ancient and recent selective pressures shaped genetic diversity at AIM2-like nucleic acid sensors.

Genome biology and evolution - 1 Apr 2014

Cagliani Rachele, Forni Diego, Biasin Mara, Comabella Manuel, Guerini Franca R, Riva Stefania, Pozzoli Uberto, Agliardi Cristina, Caputo Domenico, Malhotra Sunny, Montalban Xavier, Bresolin Nereo, Clerici Mario, Sironi Manuela

Abstract excerpt

AIM2-like receptors (ALRs) are a family of nucleic acid sensors essential for innate immune responses against viruses and bacteria. We performed an evolutionary analysis of ALR genes (MNDA, PYHIN1, IFI16, and AIM2) by analyzing inter- and intraspecies diversity. Maximum-likelihood analyses indica...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chlorocebus aethiops
Share to COS Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to Gorilla gorilla

Share to Macaca fascicularis

Share to Pan troglodytes

Share to Pongo pygmaeus

Share to Selection, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 24682156
DOI: 10.1093/gbe/evu066
PMCID: PMC4007548

Genes

IFI16
AIM2
MNDA
PYHIN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24682156-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ancient and recent selective pressures shaped genetic diversity at AIM2-like nucleic acid sensors.PMID 24682156Read ↗

Impact of nsSNPs in human AIM2 and IFI16 gene: a comprehensive in silico analysis.Semantic proximity Read ↗

[Innate immunity and human diseases: from archaic introgression to natural selection].Semantic proximity Read ↗

Evolutionary genetic dissection of human interferonsSemantic proximity Read ↗

Balancing selection is the main force shaping the evolution of innate immunity genes.Semantic proximity Read ↗

Genome-scale detection of positive selection in 9 primates predicts human-virus evolutionary conflictsSemantic proximity Read ↗

The selective footprints of viral pressures at the human RIG-I-like receptor family.Semantic proximity Read ↗

Rapid evolution of primate type 2 immune response factors linked to asthma susceptibilitySemantic proximity Read ↗

A haplotype at STAT2 Introgressed from neanderthals and serves as a candidate of positive selection in Papua New Guinea.Semantic proximity Read ↗

Rapid Evolution of Primate Type 2 Immune Response Factors Linked to Asthma Susceptibility.Semantic proximity Read ↗

Population genetics of IFIH1: ancient population structure, local selection, and implications for susceptibility to type 1 diabetes.Semantic proximity Read ↗

An evolutionary analysis of RAC2 identifies haplotypes associated with human autoimmune diseases.Semantic proximity Read ↗

SIGLEC16 encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.