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Article

Impact of nsSNPs in human AIM2 and IFI16 gene: a comprehensive in silico analysis.

Journal of biomolecular structure & dynamics - 1 Mar 2024

Sahoo Sthitaprajna, Son Seungwoo, Lee Hak-Kyo, Lee Jun-Yeong, Gosu Vijayakumar, Shin Donghyun

Abstract excerpt

AIM2 and IFI16 are the most studied members of AIM2-like receptors (ALRs) in humans and share a common N-Terminal PYD domain and C-terminal HIN domain. The HIN domain binds to dsDNA in response to the invasion of bacterial and viral DNA, and the PYD domain directs apoptosis-associated speck-like protein via protein-protein interactions. Hence, activation of AIM2 and IFI16 is crucial for protection against...

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PMID: 37139544
DOI: 10.1080/07391102.2023.2206907

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